Publications

Preprints

2025

Ripoll L, von Zastrow M, Blythe EE. Intersection of GPCR trafficking and cAMP signaling at endomembranes. J Cell Biol. 2025; 224 (4): e202409027. DOI: 10.1083/jcb.202409027.

2024

Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R. Profiling the proximal proteome of the activated μ-opioid receptor. Nat Chem Biol. 2024 Sep;20(9):1133-1143. PMID: 38528119; PMCID: PMC11365811.
Blythe EE, von Zastrow M. β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR. Nat Chem Biol. 2024 Mar;20(3):323-332. PMID: 37749347; PMCID: PMC10907292.

2022

Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM. State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides. Cell. 2022 Oct 13;185(21):3950-3965.e25. PMID: 36170854; PMCID: PMC9747239.

2013 - 2019

Blythe EE, Gates SN, Deshaies RJ, Martin A. Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing. Structure. 2019 Dec 3;27(12):1820-1829.e4. PMID: 31623962; PMCID: PMC6929323.
Xu ER, Blythe EE, Fischer G, Hyvönen M. Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2. J Biol Chem. 2017 Jul 28;292(30):12516-12527. PMID: 28584056; PMCID: PMC5535026.
Blythe EE, Olson KC, Chau V, Deshaies RJ. Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy. Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4380-E4388. PMID: 28512218; PMCID: PMC5465906.
Xue L, Blythe EE, Freiberger EC, Mamrosh JL, Hebert AS, Reitsma JM, Hess S, Coon JJ, Deshaies RJ. Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor. Mol Cell Proteomics. 2016 Sep;15(9):2970-86. PMID: 27406709; PMCID: PMC5013311.
Van Arnam EB, Blythe EE, Lester HA, Dougherty DA. An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline. Mol Pharmacol. 2013 Aug;84(2):201-7. PMID: 23680636; PMCID: PMC3716316.

Complete bibliography can be found on Emily's Google Scholar profile.