Publications

Peer Reviewed

2026

• Blythe EE, Fagan R, von Zastrow M. GPCR-selective effects of endocytosis on cellular signaling through the cAMP / PKA cascade. J Biol Chem. 2026; 5:111253. PMID: 41654131. 

• Wysolmerski B, Fisher NM, Dates AN, Inoue A, Blythe EE, von Zastrow M. Conformational biosensors delineate endosomal G protein regulation by GPCRs. Nat Commun. 2026. PMID: 41708633.

2025

• Ripoll L, von Zastrow M, Blythe EE. Intersection of GPCR trafficking and cAMP signaling at endomembranes. J Cell Biol. 2025; 224 (4): e202409027. PMID: 40131202.

2024

• Patel NM, Ripoll L, Peach CJ, Ma N, Blythe EE, Vaidehi N, Bunnett NW, von Zastrow M, Sivaramakrishnan S. Myosin VI drives arrestin-independent internalization and signaling of GPCRs. Nat Commun 2024 Dec 6;15(1):10636. PMID: 39638791.

• Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R. Profiling the proximal proteome of the activated μ-opioid receptor. Nat Chem Biol. 2024 Sep;20(9):1133-1143. PMID: 38528119.

• Blythe EE, von Zastrow M. β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR. Nat Chem Biol. 2024 Mar;20(3):323-332. PMID: 37749347.

2022

• Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM. State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides. Cell. 2022 Oct 13;185(21):3950-3965.e25. PMID: 36170854.

Complete bibliography can be found on Emily's Google Scholar profile.